3.0 SUBSTANCES USED FOR VALIDATION OF THE HET-CAM TEST METHOD 3.1 Rationale for the Substances Selected for Use
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چکیده
In vitro ocular test method validation studies should, ideally, evaluate an adequate sample of test substances and products from chemical and product classes that would be evaluated using the in vivo rabbit eye test method. Test substances with a wide range of in vivo ocular responses (e.g., corrosive/severe irritant to nonirritant) also should be assessed to determine any limit to the range of responses that can be evaluated by the in vitro test method.
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Eye irritation hazard of chemicals and formulations assessed by methods in vitro.
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